Nonlinear Langevin model with product stochasticity for biological networks: The case of the Schnakenberg model

Langevin equation is widely used to study the stochastic effects in molecular networks, as it often approximates well the underlying chemical master equation. However, frequently it is not clear when such an approximation is applicable and when it breaks down. This paper studies the simple Schnakenberg model consisting of three reversible reactions and two molecular species whose concentrations vary. To reduce the residual errors from the conventional formulation of the Langevin equation, the authors propose to explicitly model the effective coupling between macroscopic concentrations of different molecular species. The results show that this formulation is effective in correcting residual errors from the original uncoupled Langevin equation and can approximate the underlying chemical master equation very accurately.     

如何客观公正、科学准确的做好电煤质量检验

发电用煤质量严重下降,已引起国家有关部门的高度重视,文章就如何客观公正、科学准确的做好电煤质量检验工作提出了一些建议.     

吕梁市“引水入交”工程引水线路优化设计研究

文章从技术可行、施工难易、工程量、建成后运行管理、工程建设投资等方面入手,对吕梁市引水入交工程供水管线布置进行了优化设计研究,以确定该工程的管线最优布置方案。     

新疆某铜矿氧化铜矿石浸出小型试验研究

针对新疆某铜矿矿石性质特点,分别进行不同方案酸浸小型试验.推荐堆浸工艺进行可行性研究,堆浸铜浸出速度较快,同样粒度情况下铜浸出率较高、耗酸低、铁浸出率也较低,且细泥产生的干扰也小.     

浅析轮渡栈桥新型柔性轨道几何形位

介绍了轮渡栈桥新型柔性轨道几何形位名称术语及相关参数,阐述了柔性轨道几何形位的基本要素,分析了柔性轨道预留轨缝设置的问题。     

“人对人是狼”——霍布斯的人性理论浅析

霍布斯基于人的自然性，运用机械唯物主义的方法，形成其完整独特的人性理论。他先从人性的“自然欲望公理”推出“一切人对一切人的战争”的自然状态；再由人的“自然理性公理”归结出的自我保全原则，导出人们为了摆脱这一自然状态而付诸理性发现的自然法。     

区组大小为3的四重单纯支架

一个(K,λ)支架是一个区组集可分为若干个带洞平行类的可分组设计(K,λ)-GDD(X,G,B),每一个带洞平行类为X\Gj的一个划分,其中Gj∈G.若一个(K,λ)支架的区组集中任意两个区组是不相同的,则称它是单纯的.单纯的支架对构造单纯的可分解填充设计有很重要的作用,后者可以用来构造统计学中的均匀设计.本文通过直接构造和递推构造的方法证明了组型一致的(3,4)单纯支架存在的必要条件也是充分的.     

Solidification microstructure and phase constitution of Fe-7.5%Mo-16.5%Si ternary quasiperitectic alloy

Solidification of Fe-7.5%Mo-16.5%Si ternary quasiperitectic alloy is investigated by using differential scanning calorimetry (DSC) and drop tube containerless processing techniques.The primary phase is identified as R (Fe5Mo3Si2) and the quasiperitectic phases are τ1 (Fe5MoSi4) and Fe3Si.With the decrease of droplet diameter, the cooling rate and undercooling of the droplets in-crease rapidly.The experiment result indicates that the solidification microstructure is composed of remnant primary phase, qua-sip...     

Synthesis process of Ba-ferrites from α-FeOOH and γ-FeOOH and investigation of magnetic properties

The claviform BaFe₁₂O₁₉ crystals were synthesized by the precipitation-toptactic reaction method using α-FeOOH and γ-FeOOH as raw materials respectively. The synthesis processes of BaFe₁₂O₁₉, studied by XRD, SEM, EDS, FT-IR, and TG-DTA techniques, included preparations of precursor γ and precursor α, formations of α-Fe₂O₃ and BaFe₂O₄, and production of rod-like BaFe₁₂O₁₉ through dehydroxylation of pod-like FeOOH, followed by reactions of α-Fe₂O₃ with BaCO₃ and BaFe₂O₄. The crystallinity of α-Fe₂O₃ and BaCO₃ from precursor α was better than from precursor γ due to the direct dehydroxylation of α-FeOOH, resulting in a lower nucleation rate and better crystallinity of BaFe₂O₄. BaFe₁₂O₁₉ prepared from precursor α showed lower crystallinity and purity with a higher length-diameter ratio than from precursor γ. The VSM results proved that the appearance of final products had an important influence on magnetic properties.     

Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the involvement of CtrB in apoptosis. Exposure of RH-35 cells to H₂O₂ or palmitate induced the redistribution of lysosomal CtrB into the cytoplasm as a result of lysosomal membrane permeabilization (LMP). Suppression of CtrB significantly blocked apoptosis, while overexpression of CtrB sensitized apoptosis markedly. CtrB could cleave Bid under neutral conditions. In RH-35 cells with Bid silenced, apoptosis induced by CtrB protein was attenuated, suggesting that CtrB mediates apoptosis of RH-35 cells mainly through processing Bid. Our data also suggest that LMP occurs earlier than mitochondrial outer membrane permeabilization; Bid activation initiated by caspase-8 might be reinforced by CtrB in consequence of LMP, which causes a positive feedback loop leading to the accumulation of tBid, and results in lysosome- and mitochondrion-dependent apoptosis.